PROJECT CODE PN3-P3
Grant number 8BM/28/06/2016
Project title: New synergic biomaterials for anticancer therapy (SYNERG)
FUNDING AUTHORITY - THE NATIONAL AUTHORITY FOR SCIENTIFIC RESEARCH OF ROMANIA – UEFISCDI
Budget: 39200 RON
BILATERAL COOPERATION ROMANIA – SOUTH AFRICA REASERCH PROJECTS
Octavian Tudorel Olaru
|Maryna Van De Venter|
|„Carol Davila” University of Medicine and Pharmacy, Bucharest||Nelson Mandela Metropolitan University, Port Elizabeth|
The project continues and develops support contract research addressing a dual strategy of combining original synthesized pyrazole derivatives with extracts standardized in flavonoids in order to obtain mixtures with synergistic mechanism of action, useful in anticancer therapy. The original extracts will be prepared in accordance with current regulations from poorly exploited species belonging to indigenous flora. We will obtain new combinations from plant extracts and pyrazole compounds designed to operate on a wider range of cellular targets. These mixtures are converted into biomaterials based on intermolecular hydrogen bonds. Getting these materials is intended to improve stability and increase the bioavailability of flavonoids phytocomplexes.
The project contributes to the development of innovative materials and processes and their use in medicine.
Romanian partner will prepare plant extracts, biomaterials and pharmaceutical form and the partner from South Africa will conduct investigations on cancer cell lines regarding the effects of the extracts and biomaterials on cytotoxicity, apoptosis induction, dose-effect relations, and demonstrate the mechanisms of action at the cellular level.